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Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction

Beverley M Dancy1, Nicole Brockway1, Renjini Ramadasan-Nair1

  • 1Center for Developmental Therapeutics, Seattle Children's Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA.

Mechanisms of Ageing and Development
|December 26, 2015
PubMed
Summary

Glutathione S-transferase (GST-14) in the pharynx extends lifespan in a mitochondrial disease model by clearing damaging hydroxynonenal (HNE) without affecting reactive oxygen species.

Keywords:
Caenorhabditis elegansGlutathione S-transferaseHydroxynonenalLongevityMitochondrial respiratory chainReactive oxygen species

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