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Mussel-inspired soft-tissue adhesive based on poly(diol citrate) with catechol functionality.

Yali Ji1, Ting Ji2, Kai Liang3

  • 1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai, 201620, People's Republic of China. jiyali@dhu.edu.cn.

Journal of Materials Science. Materials in Medicine
|December 26, 2015
PubMed
Summary
This summary is machine-generated.

Inspired by mussels, new citrate-based tissue adhesives (POEC-d) show strong wet adhesion for surgical applications. These biodegradable and low-cytotoxicity materials offer promising potential in surgery.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Adhesives

Background:

  • Marine mussels' natural adhesion mechanisms inspire synthetic biomaterials.
  • Mussel adhesive proteins contain 3,4-dihydroxyphenylalanine (DOPA) for strong underwater bonding.
  • Existing synthetic DOPA-based adhesives require further optimization for surgical use.

Purpose of the Study:

  • To develop and characterize a novel citrate-based tissue adhesive (POEC-d) inspired by mussel adhesive proteins.
  • To investigate the influence of poly(ethylene oxide) (PEO) on the properties of the citrate-based adhesive.
  • To evaluate the adhesive strength, biodegradability, swelling, elasticity, and cytotoxicity of the developed POEC-d adhesive.

Main Methods:

  • Facile one-pot melt polycondensation of 1,8-octanediol, PEO, citric acid, and dopamine.
  • Characterization of adhesive properties including water solubility, swelling ratio, degradation rate, and lap shear adhesion strength on wet pig skin.
  • Assessment of mechanical properties (elasticity) and in vitro cytotoxicity.

Main Results:

  • POEC-d adhesives demonstrated water solubility at a specific PEO ratio (70%).
  • Equilibrium swelling was ~144%, degradation occurred within 1-2 weeks, and adhesives exhibited rubber-like elasticity.
  • Lap shear strength (21.7-33.7 kPa) exceeded commercial fibrin glue (9-15 kPa), with low cytotoxicity.

Conclusions:

  • The developed POEC-d adhesives exhibit strong wet adhesion, suitable biodegradability, acceptable swelling, good elasticity, and low cytotoxicity.
  • These citrate-based, mussel-inspired adhesives show significant potential for use as surgical tissue adhesives, sealants, and hemostatic agents.