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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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pH-responsive polymer-drug conjugates: Design and progress.

Xin Pang1, Yue Jiang1, Qicai Xiao1

  • 1School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 26, 2015
PubMed
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pH-responsive polymer-drug conjugates offer targeted drug delivery by releasing medication in acidic tumor environments or cellular compartments. This advanced platform enhances drug efficacy and minimizes systemic side effects.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Polymer-drug conjugates are a key platform for advanced drug delivery.
  • pH-responsive linkers enable triggered drug release in specific biological environments.

Purpose of the Study:

  • To review recent advancements in pH-responsive polymer-drug conjugates.
  • To elucidate their mechanisms, synthesis, and characterization.
  • To suggest future research directions.

Main Methods:

  • Review of current literature on pH-responsive polymer-drug conjugates.
  • Analysis of different chemical structures and architectures.
  • Discussion of synthesis and characterization techniques.

Main Results:

  • pH-responsive conjugates demonstrate selective drug delivery to tumor tissues and intracellular compartments.
  • These systems activate drugs at target sites, reducing off-target toxicity.
  • Diverse chemical strategies exist for designing these conjugates.

Conclusions:

  • pH-responsive polymer-drug conjugates represent a promising strategy for targeted and effective drug delivery.
  • Further research into their design and application can lead to improved therapeutics.
  • This technology holds potential for minimizing drug-related side effects.