Interpretation of thyroid function tests

The development of radioimmunoassays over the past 20 years has expanded our knowledge of thyroid physiology and improved our management of thyroid disease. The use of these tools in neonatal screening for congenital hypothyroidism alone has reduced the incidence of mental retardation in the industrialized world. Based on an accurate physical examination, the judicious use of immunoassays for thyroxine, triiodothyronine, and thyrotropin and the use of thyroglobulin and thyroid microsomal antibodies will allow the general physician to confidently delineate common thyroid disorders in the great majority of patients. The additional use of an ultrasensitive thyrotropin assay, thyroid scans, and fine-needle aspiration biopsy will complete the accurate diagnosis of the great majority of thyroid diseases. The ultrasensitive thyrotropin assay may become the universal thyroid function test. The major pitfalls in the use of these tests lies in the variable effect chronic illness has on the most frequently used tests: thyroxine and triiodothyronine. Tests for these thyroid hormones, which in the relatively well outpatient are highly accurate, may in the ill, hospitalized patient become very misleading.