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CRYSTALLINE RETINOPATHY FROM HYPEROXALURIA: LONG-TERM FOLLOW-UP
Amit A Sangave1, Matthew D Gearinger, David A Diloreto
1Flaum Eye Institute, University of Rochester School of Medicine, Rochester, New York.
Retinal Cases & Brief Reports
|December 26, 2015
Summary
Long-term follow-up reveals progressive macular changes in a patient with retinal oxalosis due to primary hyperoxaluria. These changes, including atrophy and fibrosis, occurred after a combined kidney and liver transplant.
Area of Science:
- Ophthalmology
- Nephrology
- Genetics
Background:
- Primary hyperoxaluria is a rare metabolic disorder leading to systemic oxalate deposition.
- Retinal oxalosis is a known, though infrequently reported, manifestation of this condition.
Observation:
- A pediatric patient with primary hyperoxaluria presented with clinical and optical coherence tomography findings indicative of oxalate crystal deposition in the retina.
- The patient underwent a combined kidney and liver transplant to manage the underlying metabolic disorder.
Findings:
- Long-term follow-up demonstrated progressive macular abnormalities, specifically retinal atrophy and fibrosis.
- These macular changes are consistent with crystalline retinopathy secondary to hyperoxaluria.
Implications:
- Combined hepatorenal transplantation may not fully halt the progression of retinal oxalosis-related macular degeneration.
- Ophthalmologists should be aware of potential long-term ocular complications in patients with primary hyperoxaluria, even post-transplant.
