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A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
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Modeling psychiatric disorders with patient-derived iPSCs

Zhexing Wen1, Kimberly M Christian1, Hongjun Song2

  • 1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Current Opinion in Neurobiology
|December 27, 2015
PubMed

Insights

Induced pluripotent stem cells (iPSCs) offer a new way to study complex psychiatric disorders. This research reviews how iPSCs can model disease and aid in developing more predictable, targeted therapeutics.

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Genetics

Background:

  • Psychiatric disorders are complex with challenging genetics and variable symptoms.
  • Current treatments lack specificity and can disrupt neural systems.
  • There is a need for rational therapeutics with higher predictability.

Purpose of the Study:

  • To review the use of induced pluripotent stem cells (iPSCs) for modeling neuropsychiatric disorders.
  • To discuss the potential of iPSCs in developing novel therapeutic strategies.

Main Methods:

  • Review of recent progress in utilizing human iPSCs.
  • Analysis of challenges in iPSC-based disease modeling and drug discovery.

Main Results:

  • iPSCs can recapitulate normal and pathological human tissue development.
  • iPSCs provide a platform for understanding disease mechanisms.
  • iPSCs facilitate drug discovery with higher predictability in humans.

Conclusions:

  • Human iPSCs represent a powerful tool for studying neuropsychiatric disorders.
  • iPSC technology offers promising avenues for developing targeted and effective therapeutics.

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