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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Published on: May 21, 2015

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Role of Paternal Antigen-Specific Treg Cells in Successful Implantation

Shigeru Saito1, Tomoko Shima1, Akitoshi Nakashima1

  • 1Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|December 27, 2015
PubMed

Maternal lymphocytes recognize fetal antigens, so tolerance is necessary to prevent rejection. Seminal plasma is important for induction of paternal antigen-specific Treg cells in the uterine draining lymph nodes and the pregnant uterus. Elimination of Treg cells during implantation or early pregnancy induces implantation failure or fetal resorption in mice. Immunosuppressive therapy with an anti-TNF antibody or the immunosuppressive agent tacrolimus improves the pregnancy rate in women with repeated implantation failure and recurrent pregnancy loss of unknown etiology, suggesting that Treg cells play an essential role in successful implantation and pregnancy in humans.

Keywords:
Allograft rejectioneffector Tregimmunoactivationimmunosuppressionseminal plasma

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