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Related Experiment Video

Updated: Mar 28, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Thermo-sensitive imprinted polymer embedded carbon dots using epitope approach.

Dong-Yan Li1, Xue-Mei Zhang1, Yun-Jing Yan1

  • 1College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China.

Biosensors & Bioelectronics
|December 29, 2015
PubMed
Summary

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Researchers developed a novel thermo-sensitive receptor using carbon dots/SiO2/molecularly imprinted polymer (CDs/SiO2/MIP) for selective protein detection. This innovative material offers sensitive and precise quantification of cytochrome c (cyt c).

Area of Science:

  • Materials Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Developing selective and sensitive biosensors is crucial for early disease detection and monitoring.
  • Molecularly imprinted polymers (MIPs) offer high specificity but often lack integrated sensing capabilities.
  • Carbon dots (CDs) provide excellent fluorescence properties for signal transduction.

Purpose of the Study:

  • To create a novel thermo-sensitive receptor based on carbon dots, SiO2, and molecularly imprinted polymer (CDs/SiO2/MIP).
  • To achieve selective and sensitive detection of target proteins, specifically cytochrome c (cyt c).
  • To investigate the temperature-responsive behavior of the imprinted polymer for enhanced recognition.

Main Methods:

  • Surface imprinting procedure and epitope approach were employed for receptor synthesis.
Keywords:
Carbon dotsEpitope approachFluorescent recognitionMolecularly imprinted polymer

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  • Fluorescence quenching was utilized as the detection mechanism.
  • The receptor's performance was evaluated for selectivity, sensitivity, and precision using cytochrome c.

    • Main Results:

    • The CDs/SiO2/MIP receptor demonstrated selective capture of cytochrome c, leading to fluorescence quenching.
    • A linear relationship was observed between fluorescence quenching and cytochrome c concentration from 0.1-40 μM.
    • The sensor achieved a low detection limit of 89 nM with good precision (3.11% at 20 μM).
    • The receptor exhibited thermo-sensitive properties, with swelling/shrinking influencing target recognition.

    Conclusions:

    • A feasible strategy for fabricating thermo-sensitive imprinted polymers using CDs and surface imprinting was established.
    • The developed CDs/SiO2/MIP receptor shows promise for sensitive and selective protein detection.
    • The integration of temperature sensitivity offers a novel dimension for advanced biosensing applications.