Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Identifying Statistically Significant Differences: The F-Test01:14

Identifying Statistically Significant Differences: The F-Test

4.2K
The F-test is used to compare two sample variances to each other or compare the sample variance to the population variance. It is used to decide whether an indeterminate error can explain the difference in their values. The underlying assumptions that allow the use of the F-test include the data set or sets are normally distributed, and the data sets are independent of each other. The test statistic F is calculated by dividing one variance by another. In other words, the square of one standard...
4.2K
Equivalence: In Vitro and In Vivo Bioequivalence01:17

Equivalence: In Vitro and In Vivo Bioequivalence

333
Bioequivalence studies are crucial in evaluating whether new drugs can match an approved one regarding pharmacological effects and clinical performance. These studies test if drugs, despite different dosage forms, share identical plasma concentration-time profiles. Three types of equivalence are central to these studies: chemical, pharmaceutical, and therapeutic. Chemical equivalence indicates that two or more drug products contain identical active ingredients in equal amounts. Pharmaceutical...
333
Drug Product Performance: In Vitro–In Vivo Correlation01:20

Drug Product Performance: In Vitro–In Vivo Correlation

374
In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while...
374
Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

323
The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
323
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

4.2K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
4.2K
Unusual Results01:16

Unusual Results

4.2K
Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ  from the mean, μ  is considered unusual.
Maximum unusual value =...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What Child Oral Health-Related Behaviors Can First-time Mothers Actualize? A Pragmatic Prospective Study.

JDR clinical and translational research·2019
Same author

Adapting the eButton to the Abilities of Children for Diet Assessment.

Proceedings of Measuring Behavior 2016 : 10th International Conference on Methods and Techniques in Behavioral Research. International Conference on Methods and Techniques in Behavioral Research (10th : 2016 : Dublin, Ireland)·2019
Same author

The IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) trial outcomes and process evaluations.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2015
Same author

The IDEFICS intervention trial to prevent childhood obesity: design and study methods.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2015
Same author

Obesity status transitions across the elementary years: use of Markov chain modelling.

Pediatric obesity·2015
Same author

How Many Days Was That? Intra-individual Variability and Physical Activity Assessment.

Research quarterly for exercise and sport·2015
Same journal

Life Satisfaction and Obesity Across the Lifespan: A Scoping Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same journal

Photovoice as a Methodology in Obesity Research: A Scoping Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same journal

Efficacy and Safety of Bariatric Surgery in Acquired Hypothalamic Obesity: A Systematic Review and Individual Patient Data Meta-Analysis.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same journal

Letter to the Editor: Comment on "Understanding Impact of Anti-Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods".

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same journal

What Outcome Measurement Instruments Are Used to Measure Caregiver Infant-Feeding Practices and the Feeding Environment: A Scoping Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same journal

The Influence of Relationships Within Behavioral Weight Management Interventions: An Overview.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K

Should the IDEFICS outcomes have been expected?

T Baranowski1, L Lytle2

  • 1USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|December 29, 2015
PubMed
Summary
This summary is machine-generated.

The large-scale IDEFICS obesity prevention intervention in children failed to meet its goals. Complex relationships between behaviors, adiposity, and biological factors require further investigation for future interventions.

Keywords:
Obesity preventionchildrenmediating variables

More Related Videos

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

37.6K
Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.3K

Related Experiment Videos

Last Updated: Mar 28, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K
Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

37.6K
Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.3K

Area of Science:

  • Pediatric obesity prevention research
  • Public health interventions
  • Behavioral science in health

Background:

  • Childhood obesity is a significant public health concern.
  • Multi-level interventions are often employed to combat obesity.
  • Previous interventions have shown mixed results.

Purpose of the Study:

  • To evaluate the effectiveness of the IDEFICS intervention.
  • To analyze reasons for the intervention's lack of success.
  • To inform future obesity prevention strategies.

Main Methods:

  • A comprehensive, multi-level, culturally adapted obesity prevention intervention.
  • Targeted multiple levels of influence across eight European countries.
  • Evaluated adiposity and behavior change objectives.

Main Results:

  • The IDEFICS study did not achieve its targeted adiposity or behavior change objectives.
  • Identified lack of consistent relationships between obesogenic behaviors and adiposity.
  • Highlighted weak relationships between behavioral change procedures and targeted behaviors.

Conclusions:

  • Future obesity prevention requires a deeper understanding of complex relationships, including biological factors.
  • Systems modeling and simpler community interventions are needed.
  • Longitudinal or experimental studies are crucial for validating relationships.