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Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during

Maria Isabel Saraiva Dinelli1, Erika Ono1, Patrícia Oliveira Viana1

  • 1Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.

Vaccine
|December 29, 2015
PubMed

Insights

Infants born to mothers on immunosuppressive drugs showed normal antibody responses to key vaccines. Despite initial low lymphocyte counts, these children developed protective immunity, indicating safe vaccination outcomes.

Area of Science:

  • Immunology
  • Pediatrics
  • Transplantation

Background:

  • Immunosuppressive drugs can affect fetal immune development and infant vaccination responses.
  • Limited data exists on the impact of maternal immunosuppression during pregnancy on infant immunity.

Purpose of the Study:

  • To evaluate humoral immune response and vaccine reactogenicity in infants born to renal transplant mothers on immunosuppressants.
  • To assess the influence of maternal immunosuppressive therapy on infant immune development and response to vaccination.

Main Methods:

  • Compared 27 infants of renal transplant mothers (Tx) with 31 healthy controls.
  • Assessed antibody responses to tetanus, Haemophilus influenzae type b (Hib), and pneumococcal vaccines via ELISA.
  • Performed lymphocyte immunophenotyping at birth and 8 months.
  • Monitored BCG vaccine scar evolution.

Main Results:

  • Tx neonates had lower B lymphocyte counts (82.4%) and other lymphocyte subpopulations (29.4%) at birth.
  • All infants, regardless of maternal immunosuppression, developed protective antibody levels similar to controls.
  • Vaccine reactogenicity and BCG scar healing were comparable between Tx and control groups.

Conclusions:

  • Infants born to mothers on immunosuppressive drugs demonstrate adequate humoral immune responses to standard infant vaccinations.
  • Maternal immunosuppression does not appear to compromise protective antibody development in infants.
  • These findings support the safety and efficacy of routine infant vaccinations in this population.

Keywords:
GestationImmunizationImmunosuppressionSolid organ transplantationVaccine

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