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Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
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Combination of mitochondrial myopathy and biventricular hypertrabeculation/noncompaction
Jing Wang1, Xiangquan Kong1, Ping Han1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Neuromuscular Disorders : NMD
|December 29, 2015
Summary
This study highlights a rare case of biventricular hypertrabeculation (LVHT/LVNC) in a woman with mitochondrial myopathy. The findings suggest a potential link between cardiac abnormalities and this neuromuscular disorder.
Area of Science:
- Cardiology
- Neurology
- Genetics
Background:
- Left ventricular hypertrabeculation/noncompaction (LVHT/LVNC) is a cardiac abnormality with an unclear etiology.
- While typically affecting the left ventricle, biventricular involvement is occasionally reported.
Observation:
- A 31-year-old woman presented with exercise-induced muscle weakness and mild cardiac symptoms.
- Diagnostic tests revealed mitochondrial myopathy, characterized by abnormal serum markers and muscle biopsy findings.
Findings:
- Transthoracic echocardiography and MRI confirmed biventricular hypertrabeculation in the patient.
- The case demonstrates a co-occurrence of mitochondrial myopathy and biventricular cardiac abnormalities.
Implications:
- This case suggests a potential association between mitochondrial myopathy and biventricular hypertrabeculation.
- Further research is warranted to explore the underlying mechanisms and genetic links.
- Understanding this association may improve diagnostic and therapeutic strategies for patients with overlapping conditions.
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