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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Mar 28, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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[Melanoma behavior according to age].

Francisco Schlottmann1, María Elena Peña, José M Álvarez Gallesio

  • 1Servicio de Cirugía General, Departamento de Cirugía, Hospital Alemán de Buenos Aires, Argentina.

Medicina
|December 29, 2015
PubMed
Summary

Melanoma in patients over 65 is more aggressive, with higher rates of recurrence and distant metastases compared to younger individuals. This study highlights age-related differences in cutaneous melanoma behavior and outcomes.

Keywords:
ageelderliesmelanoma

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Area of Science:

  • Dermatology
  • Oncology
  • Geriatrics

Context:

  • Increasing incidence of melanoma in elderly patients presents challenges due to immune decline and tumor aggressiveness.
  • Understanding age-related differences in melanoma behavior is crucial for effective patient management.

Purpose:

  • To evaluate the behavior and oncologic outcomes of cutaneous melanoma specifically in relation to patient age.
  • To compare histopathological variables and disease progression between melanoma patients under 65 and over 65 years old.

Summary:

  • A study of 388 melanoma patients (Group 1: <65 years, Group 2: >65 years) found Group 2 had thicker melanomas (Breslow >4mm), higher ulceration rates, and more distant metastases.
  • While nodal involvement was similar, Group 2 experienced higher disease recurrence (26% vs. 17%).
  • Specific mortality did not differ significantly between age groups.

Impact:

  • Cutaneous melanoma in patients over 65 demonstrates increased aggressiveness, characterized by higher rates of local recurrence and distant metastases.
  • Findings emphasize the need for tailored monitoring and treatment strategies for elderly melanoma patients.
  • This research contributes to understanding geriatric oncology and improving outcomes for older adults with melanoma.