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Nesidioblastosis in adults.
A Chines1, L Fogelfeld, L Zaidel
1Department of Medicine D, Edith Wolfson Medical Center, Holon, Israel.
Israel Journal of Medical Sciences
|August 1, 1989
Summary
Nesidioblastosis, a rare pancreatic condition causing hyperinsulinemic hypoglycemia, was identified in an adult patient. This case, the first reported in Israel, highlights the importance of considering this diagnosis in adults with unexplained hypoglycemia.
Area of Science:
- Endocrinology
- Gastroenterology
- Pathology
Background:
- Hyperinsulinemic hypoglycemia is a rare condition characterized by excessive insulin secretion leading to low blood glucose levels.
- Nesidioblastosis, typically diagnosed in infants, involves abnormal proliferation of islet cells in the pancreas.
- Adult-onset nesidioblastosis is exceedingly rare, with limited documented cases globally.
Observation:
- A 75-year-old female patient presented with hyperinsulinemic hypoglycemia.
- The patient's death was attributed to acute myocardial infarction with ventricular rupture.
- Microscopic pancreatic examination revealed nesidioblastosis as the cause of hypoglycemia.
Findings:
- The pancreatic histology showed enlarged, irregular islets of Langerhans.
- Clusters of islet cells were observed in close proximity to pancreatic ducts, consistent with nesidioblastosis.
- This represents the first reported case of adult nesidioblastosis in Israel.
Implications:
- This case expands the known spectrum of nesidioblastosis presentation.
- It underscores the need for thorough pancreatic evaluation in adult patients with persistent hyperinsulinemic hypoglycemia.
- Further research into adult-onset nesidioblastosis may improve diagnostic and therapeutic strategies.