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Updated: Mar 28, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Published on: November 1, 2017
Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease
Paola Briata1, Domenico Bordo1, Margherita Puppo1
1Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
Abstract:
The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer.
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