[Cellular Immune Therapy for Epstein-Barr Virus Infection after Hematopoietic Stem Cell Transplantation]

Hematopoietic stem cell transplantation is an effective method for treatment of hematologic malignancies. Due to the use of immunosuppressive agents and a long time of immune restoration after transplantation, the incidence of virus infection is high. Epstein-Barr virus (EBV) infection is a common viral infection after transplantation. In spite of the low incidence of post transplantation lymphoproliferative disorder (PTLD) caused by EBV, this disease is characte-rized by rapid progression and high mortality. T lymphocytes play an important role in anti-viral immunity, and the cellular immune therapy based on virus-specific cytotoxic T lymphocyte (CTL) is safe and efficient. This review presents the domestic and foreign advances in cellular immune treatment against EBV infection, and explores the clinical application prospects as well as problems.