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Changes in prostate cancer grading: Including a new patient-centric grading system
Oleksandr N Kryvenko1, Jonathan I Epstein2
1Department of Pathology and Laboratory Medicine, Department of Urology, and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
The Prostate
|December 29, 2015
Summary
The Gleason grading system for prostate cancer has been updated. A 2014 consensus conference defined new grade patterns and proposed a revised system for better patient care.
Area of Science:
- Uropathology
- Oncology
- Cancer Grading Systems
Background:
- The Gleason grading system, established in the 1960s, revolutionized prostate cancer classification.
- International Society of Urologic Pathology (ISUP) revisions occurred in 2005.
- Evolving understanding of prostate cancer necessitated an update to the grading system.
Purpose of the Study:
- To describe the background and rationale for revising the prostate cancer grading system.
- To propose a new grading system based on consensus findings.
- To provide guidelines for the clinical implementation of the revised system.
Main Methods:
- A consensus conference was held in November 2014 with ISUP experts and global prostate cancer leaders.
- The conference involved defining various grade patterns.
- Expert consensus guided the proposal of a new grading system.
Main Results:
- A new prostate cancer grading system was proposed.
- Specific grade patterns were defined.
- Guidelines for clinical implementation were developed.
Conclusions:
- The revised grading system aims to improve the individualized management of prostate cancer patients.
- The consensus process ensured a comprehensive update based on current scientific knowledge.
- Clinical implementation guidelines will facilitate the adoption of the new system.
