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Related Experiment Video

Updated: Mar 28, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
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Microfluidics for cell-based high throughput screening platforms - A review.

Guansheng Du1, Qun Fang2, Jaap M J den Toonder3

  • 1Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China; Department of Mechanical Engineering, Materials Technology Institute, Institute of Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, 5600 MB, The Netherlands.

Analytica Chimica Acta
|December 29, 2015
PubMed
Summary

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This summary is machine-generated.

Microfluidics technology enhances cell-based high-throughput screening for drug discovery. This review covers perfusion, droplet, and microarray methods, discussing future platform development.

Area of Science:

  • Biotechnology
  • Cell Biology
  • Drug Discovery

Background:

  • Microfluidics techniques for cell handling (culture, separation, lysis) are well-established.
  • Microfluidics is applied in PCR, immunoassays, organ-on-chip, stem cells, and circulating tumor cell analysis.
  • High-throughput screening (HTS) is crucial for rapid, large-scale drug discovery analysis.

Purpose of the Study:

  • To review the applications of microfluidics in cell-based high-throughput screening.
  • To discuss various microfluidic screening methods for drug discovery.
  • To explore future developments in microfluidic HTS platforms.

Main Methods:

  • Summarizes microfluidic applications in cell-based HTS.
  • Discusses screening methods including perfusion flow, droplet, and microarray modes.
Keywords:
Cell-based microfluidicsDrug discoveryHigh throughput screening

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  • Reviews advancements in microfluidic technology for biological assays.

    • Main Results:

    • Microfluidics enables efficient cell handling and analysis in various biological fields.
    • Perfusion, droplet, and microarray modes offer distinct advantages for microfluidic screening.
    • Microfluidic platforms facilitate rapid, parallel analysis essential for HTS.

    Conclusions:

    • Microfluidics significantly advances cell-based high-throughput screening for drug discovery.
    • Diverse microfluidic approaches cater to different screening needs.
    • Future microfluidic platforms promise enhanced capabilities for drug development.