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Paediatric HIV: Progress on Prevention, Treatment and Cure.
Maria H Kim1, Saeed Ahmed1, Elaine J Abrams2
1Baylor College of Medicine, Department of Pediatrics, Section of Retrovirology, Houston, Texas, USA ; Baylor College of Medicine-Abbott Fund Children's Clinical Center of Excellence, Lilongwe, Malawi.
Current Pediatrics Reports
|December 29, 2015
Summary
Pediatric HIV prevention and treatment have advanced significantly, nearing elimination goals. Challenges in retaining mothers and infants in care persist, but early treatment shows promise for remission.
Area of Science:
- Pediatrics
- Infectious Diseases
- Virology
Background:
- Pediatric HIV infection has seen remarkable progress in prevention and treatment.
- New strategies for preventing mother-to-child transmission are bringing the world closer to eliminating pediatric HIV.
Purpose of the Study:
- To provide an update on current developments in prevention, treatment, and cure strategies for pediatric HIV.
- To highlight progress and ongoing challenges in the field of pediatric HIV.
Main Methods:
- This is a review article, synthesizing current research and clinical developments.
- No specific experimental methods are detailed; it relies on existing literature and data.
Main Results:
- Significant progress in preventing mother-to-child transmission, though retention remains a challenge.
- Early antiretroviral therapy (ART) shows potential in reducing the HIV-1 reservoir and achieving prolonged remission.
- An increasing array of ART options is available for pediatric patients with reassuring long-term safety data.
Conclusions:
- While cure has not been achieved, early identification and treatment of HIV-infected newborns are crucial.
- Challenges remain in timely identification, treatment initiation, and retention of children and adolescents in care.
- Despite challenges, international commitments and global support offer a hopeful future for pediatric HIV management.
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