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High-density lipoprotein function in rheumatoid arthritis

Michelle J Ormseth1, C Michael Stein

  • 1Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Current Opinion in Lipidology
|December 29, 2015
PubMed

Insights

Rheumatoid arthritis (RA) patients show altered high-density lipoprotein (HDL) function, impacting cardiovascular risk. Further research is needed to clarify HDL

Area of Science:

  • Cardiovascular Research
  • Rheumatology
  • Lipid Metabolism

Background:

  • Patients with rheumatoid arthritis (RA) exhibit accelerated atherosclerosis.
  • Lipoprotein function, not just concentration, may better predict cardiovascular risk in RA.
  • Understanding high-density lipoprotein (HDL) function is crucial for assessing atherosclerosis risk in RA.

Purpose of the Study:

  • To review current research on HDL function in rheumatoid arthritis patients.
  • To summarize findings on HDL's antioxidant and cholesterol efflux capacities in RA.

Main Methods:

  • Review of existing scientific literature on HDL function and RA.
  • Analysis of studies examining HDL's antioxidant and cholesterol efflux properties in RA patients compared to controls.

Main Results:

  • HDL's antioxidant capacity shows an inverse association with inflammation and RA disease activity.
  • Consensus is lacking on whether HDL antioxidant capacity is significantly altered in RA.
  • There is no clear consensus on whether HDL cholesterol efflux capacity is altered in RA or influenced by disease activity.

Conclusions:

  • Further studies are required to consolidate data and establish consensus on HDL function in RA.
  • Research evaluating the impact of diverse HDL functions on cardiovascular disease in RA is essential.
Abstract

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