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Fibrillary glomerulonephritis associated with limited scleroderma: a case report
Clinical Nephrology
|December 29, 2015
Summary
Fibrillary glomerulonephritis, a rare kidney disease, was diagnosed in a woman with scleroderma. This is the first reported case linking fibrillary GN to limited scleroderma, with stable kidney function observed.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Fibrillary glomerulonephritis (GN) is a rare kidney disease often linked to other systemic conditions.
- Associated conditions include monoclonal gammopathies, malignancies, chronic infections, and autoimmune disorders.
Observation:
- A 56-year-old woman with limited scleroderma and a history of discoid lupus presented with hematuria.
- Her kidney function was preserved, and initial serological tests were negative.
Findings:
- Kidney biopsy confirmed the diagnosis of fibrillary GN.
- The patient maintained stable renal function and proteinuria for four years post-diagnosis.
Implications:
- This case represents the first documented instance of fibrillary GN associated with limited scleroderma.
- Highlights the importance of considering fibrillary GN in patients with autoimmune conditions, even with preserved renal function.
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