Related Experiment Video
Updated: Mar 28, 2026

Intracellular Refolding Assay
Published on: January 24, 2012
Heat shock proteins and their association with major pediatric malignancies
Dorota Skora1, Magdalena Gorska2
1Department of Medical Chemistry, Medical University of Gdansk, Gdansk 80-211, Debinki 1 Street, Poland.
Abstract:
Heat shock proteins belong to a group of molecular chaperones responsible for the regulation of many intracellular processes. HSPs play a pivotal role in the survival of cells under stressful conditions. Over-expression of these proteins have been found in both healthy and a great number of cancer cells. HSPs may be involved in numerous carcinogenic and chemoresistant processes. Due to that fact, they may be referred to as diagnostic biomarkers of oncogenesis and potential targets for anticancer drugs. Thus, we decided to review the involvement of major HSPs in the most malignant childhood cancers.
Related Concept Videos
Bacterial Protein Maturation
Other Stress Responses in Bacteria
Molecular Chaperones and Protein Folding
The...
Molecular Chaperones and Protein Folding
The JAK-STAT Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

