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Updated: Mar 28, 2026
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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
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Stem cells, telomerase regulation and the hypoxic state
Juanita Mathews1, Philip M C Davy2, Lauren H Gardner1
1Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo Street, Honolulu, HI.
Frontiers in Bioscience (Landmark Edition)
|December 29, 2015
Summary
Hypoxia inducible factor 1 alpha (Hif1alpha) is crucial for stem cell function. It enhances stem cell self-renewal, promotes glycolytic metabolism, and increases telomerase expression, vital for stem cell maintenance.
Area of Science:
- Cellular Biology
- Stem Cell Research
- Molecular Biology
Background:
- Cellular responses to low oxygen (hypoxia) are governed by hypoxia-inducible factors.
- Hypoxia-inducible factor 1 alpha (Hif1alpha) is a key regulator of cellular stress response to hypoxia.
- Emerging evidence highlights Hif1alpha's significant role in various stem cell types.
Purpose of the Study:
- To elucidate the specific roles of Hif1alpha in stem cell biology.
- To understand how Hif1alpha influences stem cell self-renewal, metabolism, and longevity.
Main Methods:
- Review of existing literature on Hif1alpha and stem cells.
- Analysis of studies investigating Hif1alpha's impact on embryonic, neuronal, and hematopoietic stem cells.
Main Results:
- Hif1alpha enhances the self-renewal capacity of stem cells.
- Hif1alpha mediates a metabolic shift towards glycolysis in stem cells.
- Hif1alpha promotes the expression of telomerase, an enzyme critical for cell longevity.
Conclusions:
- Hif1alpha is a critical regulator of stem cell properties.
- Understanding Hif1alpha's functions offers insights into stem cell maintenance and therapeutic potential.
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