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New insights into the activation, interaction partners and possible functions of MK5/PRAK

Maria Perander1, Stephen M Keyse2, Ole-Morten Seternes3

  • 1Department of Medical Biology, UiT-The Arctic University of Norway, N9037 Tromsoe, Norway.

Frontiers in Bioscience (Landmark Edition)
|December 29, 2015
PubMed

Insights

MAP kinase-activated protein kinase 5 (MK5) is activated by ERK3/ERK4 MAP kinases, not just p38. Research clarifies MK5

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • MAP kinase-activated protein kinase 5 (MK5), also known as PRAK, was initially identified as a p38 MAP kinase pathway target.
  • Recent findings reveal MK5 interacts with atypical MAP kinases ERK3 and ERK4, influencing its activation and localization.

Purpose of the Study:

  • To clarify the roles of different MAP kinase pathways in MK5 activation and function.
  • To review recent advancements in understanding the ERK3/ERK4-MK5 signaling axis.

Main Methods:

  • Review of recent literature on MK5 signaling pathways.
  • Analysis of novel upstream components and interaction partners of the ERK3/ERK4 pathway.
  • Investigation of MK5 activation mechanisms by ERK3/ERK4.

Main Results:

  • Progress in identifying novel upstream regulators of the ERK3/ERK4 signaling pathway.
  • Enhanced understanding of how ERK3 and ERK4 activate MK5 through direct interaction.
  • Discovery of new proteins that interact with MK5.

Conclusions:

  • The ERK3/ERK4 pathway plays a significant role in MK5 activation and function, challenging the sole reliance on the p38 pathway.
  • MK5 is implicated in diverse physiological and pathophysiological processes, including neuronal function and cancer.
  • Further research is needed to fully elucidate the complex roles of MK5 in cellular signaling and disease.

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