Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.9K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.9K
Protein Networks02:26

Protein Networks

4.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.7K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

7.1K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
7.1K
Protein-protein Interfaces02:04

Protein-protein Interfaces

15.0K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
15.0K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

19.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
19.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistin, an adipocytokine, offers protection against acute myocardial infarction.

Journal of molecular and cellular cardiology·2007
Same author

Liquid chromatographic analysis of phosphoamino acids at femtomole level using chemical derivatization with N-hydroxysuccinimidyl fluorescein-O-acetate.

Analytica chimica acta·2007
Same author

6-oxy-(acetyl piperazine) fluorescein as a new fluorescent labeling reagent for free fatty acids in serum using high-performance liquid chromatography.

Journal of chromatography. A·2007
Same author

Synthesis and fluorescence properties of 5,7-diphenylquinoline and 2,5,7-triphenylquinoline derived from m-terphenylamine.

Molecules (Basel, Switzerland)·2007
Same author

[Metabolic engineering of terpenoids in plants].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2007
Same author

Hedgehog signaling in the murine melanoma microenvironment.

Angiogenesis·2007

Related Experiment Video

Updated: Mar 28, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.7K

Analysis for Carom complex, signaling and function by database mining.

Suxuan Liu, Xinyu Xiong, Sam Varghese Thomas

  • 1Center for Metabolic Disease Research, Department of Pharmacology, Thrombosis Research Center, hongw@temple.edu.

Frontiers in Bioscience (Landmark Edition)
|December 29, 2015
PubMed
Summary

Researchers mapped the Carom protein's tissue expression and identified 26 partners, revealing its role in signaling pathways. Lymph nodes are key tissues for Carom, which is linked to angiogenesis and stem cell generation.

More Related Videos

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

2.0K
Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy
09:36

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy

Published on: October 19, 2018

10.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.7K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

2.0K
Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy
09:36

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy

Published on: October 19, 2018

10.0K

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Proteomics

Background:

  • Carom is a novel protein regulating membrane curvature and pathophysiological signaling.
  • Its tissue expression, functional role, and signaling pathways remain largely uncharacterized.

Purpose of the Study:

  • To elucidate the tissue expression and signaling network of the Carom protein.
  • To establish a working model for Carom's functional implications in biological processes.

Main Methods:

  • Combined database mining strategies were employed to identify Carom partners and their expression profiles.
  • Ingenuity pathway analysis was used to identify Carom partner signaling pathways.
  • Gene expression data from the GEO database was analyzed for specific conditions.

Main Results:

  • Twenty-six Carom partners were identified, with lymph nodes identified as a Tier 1 tissue for Carom and partner expression.
  • Four conditions (hypoxia, endometriosis, PPARgamma deletion, iPSC reprogramming) altered Carom/partner expression in endothelial cells.
  • Carom/ITSN1 elevation correlated with pathological angiogenesis, while Carom/HSPA5 or UBC reduction was linked to iPSC generation.

Conclusions:

  • A Carom complex model was established, providing insights into its functional roles.
  • The study highlights Carom's involvement in both pathological angiogenesis and induced pluripotent stem cell generation.
  • Identified Carom partners and pathways offer potential targets for further research.