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Bioanalytical applications of supercritical fluid chromatography
W M Niessen1, U R Tjaden, J van der Greef
1Division of Analytical Chemistry, Center for Bio-Pharmaceutical Sciences, RA Leiden, The Netherlands.
Abstract:
Supercritical fluid chromatography (SFC) has become a valuable tool in analytical chemistry. In the past few years considerable progress has been made in bioanalytical applications of both capillary and packed column SFC. Progress in this respect has especially been made with combined SFC-mass spectrometry, an important alternative to combined liquid chromatography-mass spectrometry. The various applications of capillary and packed column SFC are reviewed, while special attention is given to detection technique applicable in (bioanalytical) SFC. Considerable progress in SFC is expected in the near future.