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Leucoreduction of blood components: an effective way to increase blood safety?

Maria Bianchi1,2, Stefania Vaglio1,3, Simonetta Pupella1

  • 1Italian National Blood Centre, National Institute of Health, Rome, Italy.

Blood Transfusion = Trasfusione Del Sangue
|December 29, 2015
PubMed

Over the past 30 years, it has been demonstrated that removal of white blood cells from blood components is effective in preventing some adverse reactions such as febrile non-haemolytic transfusion reactions, immunisation against human leucocyte antigens and human platelet antigens, and transmission of cytomegalovirus. In this review we discuss indications for leucoreduction and classify them into three categories: evidence-based indications for which the clinical efficacy is proven, indications based on the analysis of observational clinical studies with very consistent results and indications for which the clinical efficacy is partial or unproven.

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