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[Clinical evaluation of cell population data parameters in predicting engraftment after hematopoietic stem cell
Ying Xing1, Chenxue Qu2, Meiling Wang1
1Clinical Laboratory, Peking University First Hospital, Beijing 100034, China.
Objective:
To explore the cell population data (CPD) parameters of DxH800 hematology analyzer in predicting engraftment after hematopoietic stem cell transplantation.
Methods:
Data from 109 patients who underwent hematopoietic stem cell transplantation at Peking University First Hospital between July 2013 and September 2014 were selected, all CBC data including CPD parameters from the beginning to engraftment (absolute neutrophil count > 500/µl) were gathered and analyzed to find the early markers of myeloid engraftment and establish the cut-off value.
Results:
The makers which could predict myeloid engraftment were mean neutrophil volume (MNV) and mean monocyte volume (MMV), the cut-off value was ≥ 180 fl and ≥ 190 fl, respectively, and engraftment was predicted earlier (2.2 ± 1.3) days and (2.3 ± 1.7) days than absolute neutrophil count.
Conclusion:
By analyzing the CPD data of DxH800 hematology analyzer, engraftment can be predicted approximately 2 days earlier than absolute neutrophil count.
