[Perspective randomized control study on different NSAIDs drugs after rotator cuff repair]

Area of Science:

• Orthopedics and Traumatology
• Pharmacology
• Pain Management

Background:

• Rotator cuff repair is a common orthopedic procedure.
• Effective pain management and functional recovery are crucial post-surgery.
• Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used to manage postoperative pain.

Purpose of the Study:

• To compare the efficacy and safety of ibuprofen, celecoxib, and flurbiprofen axetil in managing pain and improving function after arthroscopic rotator cuff repair.
• To evaluate the impact of these COX inhibitors on patient recovery and potential side effects.

Main Methods:

• A randomized controlled trial involving 63 patients undergoing arthroscopic rotator cuff repair.
• Patients were divided into three groups, receiving either flurbiprofen axetil, ibuprofen, or celecoxib for five consecutive days post-operation.
• Pain was assessed using the Visual Analogue Scale (VAS), alongside shoulder function scores and range of motion measurements.

Main Results:

• Flurbiprofen axetil showed significantly better pain relief from postoperative day 4 compared to ibuprofen and celecoxib (P<0.05).
• All groups demonstrated significant improvements in VAS scores, shoulder function, and range of motion one year post-surgery.
• Incidence of side effects was 9.5% for flurbiprofen axetil, 14.3% for celecoxib, and 33.3% for ibuprofen, with no significant inter-group differences.

Conclusions:

• Flurbiprofen axetil offers enhanced pain control post-arthroscopic rotator cuff repair compared to ibuprofen and celecoxib.
• All three evaluated COX inhibitors are highly effective and safe for patients undergoing rotator cuff repair.
• No adverse effects on tendon healing were observed with any of the tested medications.