Related Experiment Video

Updated: Mar 28, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.9K

Sleep architecture and obstructive sleep apnea in obese children with and without metabolic syndrome: a case control

Shabnam Jalilolghadr1, Zohreh Yazdi2, Manoochehr Mahram1

  • 1Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Sleep & Breathing = Schlaf & Atmung
|December 30, 2015
PubMed

Insights

Obese children with metabolic syndrome experience worse sleep quality, including more awakenings and altered sleep stages. Severe obstructive sleep apnea (OSA) is independently linked to metabolic syndrome in these children.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Metabolic Disorders

Background:

  • Obesity and metabolic disorders are linked to obstructive sleep apnea (OSA).
  • Understanding the relationship between metabolic syndrome and sleep in obese children is crucial.

Purpose of the Study:

  • To compare sleep architecture and OSA prevalence in obese children with and without metabolic syndrome.
  • To investigate the association between metabolic syndrome and sleep disturbances in pediatric obesity.

Main Methods:

  • Case-control study involving 42 obese children with metabolic syndrome and 38 matched controls.
  • Utilized questionnaires (BEARS, Children's Sleep Habits Questionnaire) and polysomnography (PSG).
  • Statistical analysis included chi-square, T test, Mann-Whitney U, and logistic regression.

Main Results:

  • Children with metabolic syndrome showed longer non-rapid eye movement (NREM) sleep and N1 stage, and shorter REM sleep.
  • Increased waking after sleep onset (WASO) was observed in the metabolic syndrome group.
  • Severe OSA was more frequent in controls, but severe OSA and shorter REM sleep were independently associated with metabolic syndrome.

Conclusions:

  • Obese children with metabolic syndrome exhibit disrupted sleep architecture, including increased WASO and N1 sleep, potentially due to OSA severity.
  • Severe OSA and altered REM sleep are independently associated with metabolic syndrome in obese children.
  • Further longitudinal research is required to confirm the link between metabolic syndrome and OSA in this population.
Abstract

Keywords:
Metabolic syndrome XObesityObstructive sleep apneaPolysomnographySleep stages

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.8K
Assessment of Child Anthropometry in a Large Epidemiologic Study09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

28.0K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
756
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
281
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
379
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.2K
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.4K