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Pleiotropy

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

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Related Experiment Video

Updated: Mar 28, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Peters Anomaly

Krishna R Surapaneni¹, Michael C Struck¹, Paul O Phelps¹

¹University of Wisconsin - Madison, Department of Ophthalmology and Visual Sciences, Madison, Wisconsin.

|December 30, 2015

Summary

No abstract available in PubMed .

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