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Gamma glutamyltransferase, inflammation and cardiovascular risk factors in isolated coronary artery ectasia

Abdullah Dogan1, Akif Arslan1, Habil Yucel1

  • 1Cardiology Department, Medical School, Suleyman Demirel University, Isparta, Turkey.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|December 30, 2015
PubMed

Insights

Coronary artery ectasia (CAE) is linked to higher obesity, gamma glutamyltransferase (GGT), and high-sensitivity C-reactive protein (hs-CRP) levels. However, CAE shows an inverse association with diabetes, and its severity correlates with GGT and hs-CRP.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biomarkers

Background:

  • Conflicting data exists on cardiovascular risk factors in coronary artery ectasia (CAE).
  • The association between CAE, high-sensitivity C-reactive protein (hs-CRP), and gamma glutamyltransferase (GGT) remains unclear.

Purpose of the Study:

  • To investigate major cardiovascular risk factors, serum GGT, and hs-CRP levels in a large cohort of patients with CAE.
  • To clarify the relationship between CAE and these biomarkers and risk factors.

Main Methods:

  • Retrospective analysis of 167 patients with isolated CAE and 150 controls undergoing coronary angiography.
  • Evaluation of cardiovascular risk factors (family history, obesity, smoking, diabetes, hypertension, hyperlipidemia) and serum GGT and hs-CRP levels.

Main Results:

  • CAE patients showed higher prevalence of hypertension and obesity, and lower frequency of diabetes compared to controls.
  • Serum GGT and hs-CRP levels were significantly higher in CAE patients than in controls (p=0.001 for both).
  • CAE was independently associated with obesity (OR: 2.84), GGT (OR: 1.08), and hs-CRP (OR: 3.1), but inversely with diabetes (OR: 0.44). GGT and hs-CRP levels correlated with ectasia severity.

Conclusions:

  • Coronary artery ectasia (CAE) is independently associated with obesity, elevated GGT, and hs-CRP levels.
  • An inverse relationship exists between CAE and diabetes.
  • The severity of CAE may be positively correlated with GGT and hs-CRP levels.
Abstract

Keywords:
Coronary ectasiaEctasia coronáriaFatores de riscoGamma glutamyltransferaseGlutamiltransferaseInflamaçãoInflammationRisk factors

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