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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

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Rituximab induces clonal expansion of IgG memory B-cells in patients with inflammatory central nervous system

Michael A Maurer1, Friederike Tuller2, Viktoria Gredler2

  • 1Institute of Experimental Immunology, Department of Neuroinflammation, University of Zürich, Zürich, Switzerland.

Journal of Neuroimmunology
|December 30, 2015
PubMed

Rituximab, a monoclonal B-cell cytolytic antibody, has beneficial effects in patients with inflammatory demyelinating diseases. So far, little data exists on B-cell subset recovery after rituximab treatment in inflammatory demyelinating diseases of the central nervous system (CNS). To elucidate whether rituximab promotes qualitative changes in the IgG memory B-cell repertoire we performed a single cell analysis in three patients with CNS demyelination. We did not observe any qualitative changes but detected an increased clonal expansion in the IgG memory B-cell compartment after treatment, indicating that a single course of rituximab does not eliminate specific IgG memory B-cells.

Keywords:
B-cellsClonal expansionMultiple sclerosisNeuromyelitis opticaRituximab

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