Expression of DNA methylation genes in secondary progressive multiple sclerosis
Paolo Fagone1, Katia Mangano1, Roberto Di Marco2
1Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Journal of Neuroimmunology
|December 30, 2015
Abstract:
Multiple sclerosis (MS) is an immunoinflammatory disease of the central nervous system that seems to be influenced by DNA methylation. We sought to explore the expression pattern of genes involved in the control of DNA methylation in Secondary Progressive (SP) MS patients' PBMCs. We have found that SP MS is characterized by a significant upregulation of two genes belonging to the MBD family genes, MBD2 and MBD4, and by a downregulation of TDG and TET3.
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