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Related Experiment Videos

Vascular changes in cutaneous leishmaniasis.

M H Essa, A M Mangoud, T A Morsy

    Journal of the Egyptian Society of Parasitology
    |December 1, 1989
    PubMed
    Summary

    This study reveals immune complex formation in skin lesions causes vascular changes in human cutaneous leishmaniasis (CL). These findings highlight the role of immune responses in the pathology of CL.

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    Area of Science:

    • Dermatology
    • Immunology
    • Pathology

    Background:

    • Cutaneous leishmaniasis (CL) is a parasitic disease affecting the skin.
    • Vascular involvement in CL pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the histopathological and immunopathological changes in blood vessels of human cutaneous leishmaniasis lesions.
    • To elucidate the role of immune complexes in vascular alterations in CL.

    Main Methods:

    • Histopathological examination of 50 biopsies from patients with proven CL.
    • Immunoperoxidase staining to detect immunoglobulin deposition (IgG, IgA) in vascular tissues.

    Main Results:

    • Twenty biopsies showed vascular alterations including fibrinoid necrosis and thrombi in arteries and veins.
    • Hyalinosis and intimal proliferation were observed in diseased vessels.
    • IgG and IgA were found within endothelial cells, media, and perivascular spaces of affected vessels.

    Conclusions:

    • Immune complex formation within the infected skin appears to be responsible for the observed vascular changes in CL.
    • These findings contribute to understanding the immunopathology of cutaneous leishmaniasis.

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