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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
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Lymphedema Precautions: Time to Abandon Old Practices?
1Mount Sinai Medical Center, New York, NY.
Summary
This case study highlights a 46-year-old woman diagnosed with early-stage breast cancer. Treatment included lumpectomy, radiotherapy, and endocrine therapy, with a low recurrence risk. The patient seeks advice on preventing lymphedema during air travel.
Area of Science:
- Oncology
- Radiotherapy
- Surgical Oncology
Background:
- The Oncology Grand Rounds series contextualizes clinical research for practical application.
- This case involves a 46-year-old premenopausal woman diagnosed with early-stage invasive ductal carcinoma and ductal carcinoma in situ.
Observation:
- Screening mammography revealed a 1-cm spiculated mass with calcifications.
- Biopsy confirmed hormone receptor-positive, HER2-negative invasive ductal carcinoma.
- Final pathology showed an 8-mm tumor with clear margins and negative sentinel lymph nodes.
Findings:
- The 21-gene recurrence score was 10, indicating a 7% risk of 10-year distant recurrence with endocrine treatment.
- Adjuvant radiotherapy was completed.
- The patient, a professional violinist, is concerned about lymphedema prevention during air travel.
Implications:
- This case underscores the importance of multidisciplinary care in early-stage breast cancer management.
- It highlights the need for personalized treatment based on genomic profiling and patient-specific factors.
- Addressing patient concerns, such as lymphedema prevention, is crucial for quality of life and treatment adherence.
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