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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated

Lin Xie1, Feng-Chao Jiang1, Li-Min Zhang1

  • 1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Health, and Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China (LX, LMZ, JHL, MQL, XZ, SX, HG, PZ); Academy of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (FCJ); Department of endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (WTH).

Journal of the National Cancer Institute
|December 30, 2015
PubMed
Summary

A novel MyD88 inhibitor (TJ-M2010-5) effectively prevented colitis-associated cancer (CAC) development in mice by suppressing inflammation and promoting apoptosis. This suggests MyD88 inhibitors are a promising therapeutic strategy for treating colitis and CAC.

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