Related Experiment Video
Updated: Mar 28, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Making smart investment decisions in clinical research
Nick Bansback1,2,3, Edward Keystone4,5, James O'Dell6,7
1School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada. nick.bansback@ubc.ca.
Unlabelled:
A recent trial in rheumatoid arthritis found an inexpensive, but infrequently used, combination of therapies is neither inferior nor less safe than an expensive biologic drug. If the trial had been conducted over 10 years ago, arguably 100's of millions of dollars since spent on biologics could have been released to other, more effective treatments. Given the ever increasing number of trials proposed, this commentary uses the trial as an example to challenge payers and research funders to make smarter investments in clinical research to save potential future costs.
Trial Registration:
NCT00405275 , registered 29 November 2006.
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