Related Experiment Video
Updated: Mar 28, 2026

In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
Published on: January 2, 2026
[Research progress on ubiquitin-specific protease in antiviral immunity]
Hui-hui Zhu1, Xi-bao Zhao1, Wei-wei Hu1
1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Abstract:
Ubiquitin-specific protease(USP), which belongs to cysteine protease, is an important member of the deubiquitinating enzyme family(DUB). USP plays an important role in the immune response against viral infections, in which it can regulate the production of type I interferon through various ways to initiate or weaken the antiviral immune response. USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response. In this article we review the recent progress on roles of USP family in antiviral immune response.
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