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A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
Published on: August 7, 2017
[Research progress in kidney dendritic cells]
Rui-Ling Chen1, Jian-Ping Pan2
1Zhejiang University City College School of Medicine, Hangzhou 310015, China;Department of Pathogen Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Abstract:
Kidney dendritic cells(DC) play important roles in the pathogenesis of kidney diseases. Kidney DC presents anti-inflammatory effects in certain kidney diseases, sometimes presents pro-inflammation in other diseases, and sometimes their effects are changing in different stages of the disease, suggesting that the differentiation and function of kidney DC may be influenced by microenvironment. This article reviews the origin and distribution of kidney DC subsets and their roles in the pathogenesis of kidney diseases such as lupus nephritis and pyelonephritis, and the functional regulation of kidney DC by proximal tubule epithelial cells.
Insights
Kidney dendritic cells (DC) have dual roles in kidney disease, acting as anti-inflammatory or pro-inflammatory depending on the condition. Their function is influenced by the kidney microenvironment.
Area of Science:
- Immunology
- Nephrology
Background:
- Kidney dendritic cells (DCs) are crucial immune cells in renal pathogenesis.
- Their roles can be anti-inflammatory or pro-inflammatory, varying with disease type and stage.
- The kidney microenvironment likely influences DC differentiation and function.
Purpose of the Study:
- To review the origin and distribution of kidney DC subsets.
- To examine the roles of kidney DCs in specific kidney diseases.
- To explore how proximal tubule epithelial cells regulate kidney DC function.
Main Methods:
- Literature review of studies on kidney dendritic cells.
- Analysis of DC subsets' origins and distributions.
- Examination of DC roles in lupus nephritis and pyelonephritis.
Main Results:
- Kidney DCs exhibit diverse roles in kidney disease pathogenesis.
- DC function is context-dependent, influenced by disease and microenvironment.
- Proximal tubule epithelial cells can modulate kidney DC activity.
Conclusions:
- Kidney DCs are key players in kidney disease, with functions modulated by their environment.
- Understanding kidney DC heterogeneity is vital for therapeutic strategies.
- Further research into DC-epithelial cell interactions is warranted.
