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An Exposome Perspective on Environmental Enteric Dysfunction.

Job O Mapesa1, Amy L Maxwell, Elizabeth P Ryan

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|December 30, 2015
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Summary
This summary is machine-generated.

Environmental chemical mixtures may contribute to environmental enteric dysfunction (EED) in children. Further research using exposome approaches is needed to understand chemical exposures and their impact on gut health and stunting.

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Area of Science:

  • Environmental Health
  • Gastroenterology
  • Immunotoxicology

Background:

  • Environmental chemical exposures impact gastrointestinal function.
  • The role of chemical mixtures in environmental enteric dysfunction (EED) in children is understudied.
  • EED severely affects children in developing countries with poor sanitation.

Purpose of the Study:

  • Highlight exposome approaches to investigate chemical exposures and EED.
  • Examine the influence of toxicants on gut immune system and microbiome function.
  • Expand understanding of EED etiology beyond fecal-oral contamination.

Main Methods:

  • Utilizing exposome approaches to characterize chemical exposures.
  • Integrating data on chemical exposures, EED, and stunting across childhood.
  • Evaluating environmental chemicals as candidates for EED biomarkers.

Main Results:

  • Focus on fecal-oral contamination in EED should expand to include environmental chemicals like pesticides and heavy metals.
  • Comprehensive characterization of prenatal and early-life chemical exposures is crucial.
  • Understanding chemical exposures can reveal risks for EED and stunting.

Conclusions:

  • Integrating EED, chemical exposure, and stunting provides a more complete view of child health.
  • Etiology and intervention studies must consider environmental chemical exposures.
  • Environmental chemicals are potential contributors to EED biomarkers.