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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

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Editor's Choice- Inside the cold heart: A review of therapeutic hypothermia cardioprotection

Luis O Chavez1,2, Monica Leon1,3, Sharon Einav4

  • 11 University General Hospital, Houston, USA.

European Heart Journal. Acute Cardiovascular Care
|December 31, 2015
PubMed

Insights

Therapeutic hypothermia shows cardioprotective effects in preclinical models by stabilizing mitochondria and regulating cellular processes. Clinical trials are exploring its combination with other treatments for acute ischemic injury.

Area of Science:

  • Cardiology
  • Physiology
  • Biochemistry

Background:

  • Myocardial infarction is a leading global cause of death.
  • Targeted temperature management is used to improve outcomes after cardiac arrest.
  • Therapeutic hypothermia is being investigated for acute cardiac ischemic injury.

Purpose of the Study:

  • To review the cardioprotective properties of therapeutic hypothermia.
  • To explore the physiological and molecular mechanisms of hypothermia's effects on the cardiovascular system.
  • To summarize clinical trial outcomes and future directions.

Main Methods:

  • Systematic literature search of MEDLINE, Scopus, and EMBASE databases.
  • Review of preclinical animal studies.
  • Analysis of human clinical trials.

Main Results:

  • Preclinical studies demonstrate cardioprotective effects of therapeutic hypothermia in animals.
  • Proposed mechanisms include mitochondrial stabilization, nitric oxide production, reactive oxygen species equilibration, and calcium channel homeostasis.
  • Clinical trial results in humans are controversial, prompting research into combined treatment modalities.

Conclusions:

  • Therapeutic hypothermia exhibits potential cardioprotective effects through various molecular pathways.
  • Clinical application in acute ischemic injury requires further investigation, potentially through combination therapies.
  • Understanding hypothermia's impact on the cardiovascular system is crucial for improving patient outcomes.

Keywords:
Acute myocardial infarctioncardiac arrestdysrhythmiashypothermia

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