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Related Concept Videos

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Related Experiment Video

Updated: Mar 28, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
14:52

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Minimally Important Difference of the Absolute and Functional Claudication Distance in Patients with Intermittent

M M L van den Houten1, L N M Gommans2, P J van der Wees3

  • 1Catharina Hospital, Department of Vascular Surgery, Eindhoven, The Netherlands.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|December 31, 2015
PubMed
Summary

The minimally important difference (MID) for walking distance in intermittent claudication (IC) patients was determined. Improvements of 305m for absolute claudication distance (ACD) and 250m for functional claudication distance (FCD) are considered meaningful.

Keywords:
Intermittent claudicationPeripheral arterial diseaseSupervised exercise therapy

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Area of Science:

  • Vascular Medicine
  • Clinical Exercise Physiology
  • Patient-Reported Outcomes

Background:

  • Assessing intermittent claudication (IC) severity relies on treadmill walking distances.
  • A clear definition of a clinically meaningful change in walking distance from the patient's perspective is lacking.
  • This study aimed to establish the minimally important difference (MID) for key walking distance metrics in IC.

Purpose of the Study:

  • To estimate the minimally important difference (MID) for absolute claudication distance (ACD) and functional claudication distance (FCD) in patients with intermittent claudication (IC).
  • To provide objective benchmarks for interpreting changes in walking capacity following treatment.

Main Methods:

  • An anchor-based approach using the Walking Impairment Questionnaire (WIQ) was employed.
  • Data from 202 patients in the EXITPAD trial (supervised exercise therapy) were analyzed.
  • MIDs for improvement and deterioration were calculated based on the 95% confidence intervals of mean changes in ACD and FCD for patients with no change in WIQ scores.

Main Results:

  • The MID for ACD improvement was 305 meters; for deterioration, it was 147 meters.
  • The MID for FCD improvement was 250 meters; for deterioration, it was 120 meters.
  • These values provide quantitative measures for clinically relevant changes in walking distance.

Conclusions:

  • The established MIDs for ACD and FCD offer valuable tools for interpreting changes in walking distance after supervised exercise therapy.
  • These MIDs can enhance both clinical trial research and the care of individual patients with IC.