Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiomics-based causal machine learning for exploratory treatment-effect estimation of neoadjuvant chemotherapy cycle intensity in osteosarcoma: a proof-of-concept study.

BMC medical imaging·2026
Same author

Multi-omics analysis of the role of muskmelon mitochondria in Si-induced resistance mechanisms.

Frontiers in plant science·2026
Same author

Erratum: Efficacy and Safety of Camrelizumab Plus Apatinib in Patients With Refractory Chordoma: A Phase II Clinical Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Modification of a poroelastic model for zero porosity: finite element implementation and investigation of fluid mechanics in the perivascular space.

Biomechanics and modeling in mechanobiology·2026
Same author

Comparative effectiveness of budesonide EC and telitacicept in proteinuria and eGFR trajectories in IgA nephropathy: a retrospective cohort study.

Frontiers in immunology·2026
Same author

Institutional experience and pooled survival analysis of chemotherapy based multimodal management in poorly differentiated chordoma.

Discover oncology·2026
Same journal

Sodium-Based Battery Component Design: Imitating Lithium or Forging New Paths?

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Enhancing Birefringence of Sulphates by Polarity Modification in Planar Cations.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

In Situ Atomic-Scale Observation of Preferential Premelting at Oxide Crystal Defects.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Thickness-Dependent Semiconductor-Metal Transition in Two-Dimensional Nonlayered Magnetic CuCo<sub>2</sub>S<sub>4</sub>.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Programmable Control Over Radical and Non‑Radical Pathways in Fenton‑Like Catalysis via Carbon‑Encapsulated Iron Nanoreactors.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Self-Powered MXene@Perovskite Thermoelectric Skin for Multimodal Mid-Infrared Sensing and Human Signal Recognition.

Small (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

A Microfluidic Technique to Probe Cell Deformability
09:47

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

11.9K

Probing Cell Deformability via Acoustically Actuated Bubbles.

Yuliang Xie1, Nitesh Nama2, Peng Li2

  • 1Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|December 31, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces an acoustic bubble technique to measure cell deformability in microfluidics. This method quantifies mechanical biomarkers for cell analysis and potential biophysical diagnosis.

Keywords:
acoustic streamingacoustically actuated bubblescell deformabilitymicrofluidicsoptothermal effects

More Related Videos

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)&#8211;Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

12.3K
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.9K

Related Experiment Videos

Last Updated: Mar 28, 2026

A Microfluidic Technique to Probe Cell Deformability
09:47

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

11.9K
A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)&#8211;Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

12.3K
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.9K

Area of Science:

  • Biophysics
  • Cell Biology
  • Microfluidics

Background:

  • Cell deformability is a critical indicator of mechanical properties and cellular health.
  • Existing methods for measuring cell mechanics can be complex and time-consuming.
  • Microfluidic devices offer a controlled environment for cell manipulation and analysis.

Purpose of the Study:

  • To develop and validate an acoustically actuated, bubble-based technique for measuring cell deformability.
  • To assess the mechanical properties of different cell types (HeLa, HEK, HUVEC) and their response to treatment.
  • To demonstrate the technique's capability in analyzing heterogeneous cell populations.

Main Methods:

  • Generating a microsized bubble via optothermal effect near cells in a microfluidic chamber.
  • Employing acoustic actuation to induce localized acoustic streaming and hydrodynamic forces.
  • Measuring cell deformation in situ to determine mechanical biomarkers.

Main Results:

  • Successfully measured the mean deformability of HeLa, HEK, and HUVEC cells.
  • Observed deformation of HeLa cells upon treatment with Cytochalasin.
  • Distinguished deformability of subpopulations within mixed, heterogeneous cell samples using mechanical and fluorescent biomarkers.

Conclusions:

  • The acoustically actuated bubble technique provides a sensitive and efficient method for assessing cell mechanical properties.
  • This technique can be integrated into bioanalysis and drug-screening platforms.
  • The method holds potential for biophysical cellular diagnosis and understanding cell biology.