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Eosinophilic fasciitis.

J A Doyle1, W W Ginsburg

  • 1Skin and Cancer Foundation, Sydney, Australia.

The Medical Clinics of North America
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Fascial inflammation is increasingly recognized in various connective tissue diseases beyond scleroderma. Eosinophilic fasciitis (EF) shares features with scleroderma but differs in specific clinical and biopsy findings.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Pathology

Background:

  • Fascia received limited attention until the delineation of Eosinophilic Fasciitis (EF).
  • Accumulating evidence suggests significant fascial inflammation in conditions beyond EF and scleroderma, including polymyositis, dermatomyositis, and lupus erythematosus.
  • The relationship between EF and scleroderma remains unclear, though shared features like eosinophilia and positive autoantibodies are noted.

Purpose of the Study:

  • To explore the spectrum of fascial inflammation in connective tissue diseases.
  • To compare and contrast Eosinophilic Fasciitis (EF) with scleroderma and related conditions.
  • To highlight diagnostic distinctions based on clinical presentation and biopsy findings.

Main Methods:

  • Review of existing literature and clinical evidence.

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  • Comparative analysis of clinical features and serological markers.
  • Histopathological comparison of fascial biopsies across different conditions.

    • Main Results:

    • Significant fascial inflammation is observed in polymyositis, dermatomyositis, systemic lupus erythematosus, and mixed connective tissue disease.
    • Eosinophilic Fasciitis (EF) shares similarities with scleroderma, including eosinophilia, hypergammaglobulinemia, and positive ANA/rheumatoid factor.
    • Distinguishing EF from systemic scleroderma involves assessing the rarity of Raynaud's phenomenon and visceral changes; EF resembles localized scleroderma syndromes.

    Conclusions:

    • Fascial inflammation is a common finding in several systemic autoimmune diseases.
    • Eosinophilic Fasciitis (EF) presents a unique profile, sharing features with scleroderma but with key differentiating factors.
    • Histopathological changes in the fascia are comparable across EF, systemic scleroderma, and localized scleroderma, with differences in the affected tissue levels.