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Allergic Diseases and Internalizing Behaviors in Early Childhood

Maya K Nanda1, Grace K LeMasters2, Linda Levin2

  • 1Division of Asthma, Allergy, and Immunology, Children's Mercy Hospital, Kansas City, Missouri; maya.nandalapsiwala@gmail.com.

Pediatrics
|December 31, 2015
PubMed

Insights

Children with early childhood allergic rhinitis and wheezing face higher risks of internalizing disorders like anxiety and depression by age seven. Multiple allergic conditions amplify this risk in a dose-dependent manner.

Area of Science:

  • Pediatric Allergy and Immunology
  • Child and Adolescent Psychiatry
  • Developmental Psychology

Background:

  • The link between allergic diseases and internalizing disorders requires further investigation, especially concerning multiple conditions and longitudinal data.
  • Previous studies have not fully characterized the long-term association between early-life allergic diseases and later internalizing behaviors.

Purpose of the Study:

  • To investigate the association between multiple allergic diseases in early childhood and validated measures of internalizing disorders in school-aged children.
  • To examine the dose-dependent relationship between the number of allergic diseases and internalizing behaviors.

Main Methods:

  • Longitudinal study of 546 children from the Cincinnati Childhood Allergy and Air Pollution Study.
  • Assessment of allergic diseases (allergic rhinitis, persistent wheezing, atopic dermatitis, sensitization) at age 4.
  • Evaluation of internalizing disorders using the Behavior Assessment System for Children, Second Edition (BASC-2) at age 7, analyzed via logistic and linear regression.

Main Results:

  • Allergic rhinitis at age 4 was significantly linked to higher internalizing, anxiety, and depression scores at age 7.
  • Allergic persistent wheezing at age 4 was associated with elevated internalizing scores.
  • The presence of multiple allergic diseases at age 4 showed a dose-dependent association with increased internalizing scores.

Conclusions:

  • Early childhood allergic rhinitis and persistent wheezing increase the risk for internalizing behaviors in school-aged children.
  • A greater number of allergic diseases in early childhood is associated with a higher risk and severity of internalizing disorders.
Abstract

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