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[Aluminum poisoning].

M Cervar, A Stavljenic, S Vukicević

    Lijecnicki Vjesnik
    |April 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Aluminum intoxication is a common complication in dialysis patients, leading to bone disease and other serious health issues. Reducing aluminum intake is crucial for preventing these adverse effects in patients with chronic renal failure.

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    International orthopaedics·2007

    Area of Science:

    • Nephrology
    • Toxicology
    • Bone Metabolism

    Context:

    • Chronic renal failure (CRF) patients undergoing dialysis are at high risk for aluminum intoxication.
    • Aluminum exposure occurs via dialysate and aluminum-containing phosphate binders.
    • Accumulated aluminum leads to significant health complications, including renal osteodystrophy, encephalopathy, and anemia.

    Purpose:

    • To review the mechanisms and consequences of aluminum accumulation in patients with chronic renal failure.
    • To highlight the prevalence and types of aluminum-induced bone disease in dialysis patients.
    • To discuss the role of hyperparathyroidism in aluminum absorption and the potential preventive strategies.

    Summary:

    • Aluminum intoxication is prevalent in dialysis patients, contributing to bone disease in up to 44% of cases.

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  • Histological findings include osteomalacia and aplastic bone disease, often associated with low parathyroid hormone (PTH) levels.
  • Hyperparathyroidism exacerbates aluminum absorption, suggesting parathyroidectomy as a potential preventive measure, though lowering aluminum intake is the primary strategy.

    • Impact:

    • Understanding aluminum's role in CRF complications guides preventive measures, primarily reducing patient aluminum exposure.
    • Early diagnosis via bone biopsy is essential for managing aluminum-related bone disease.
    • Deferoxamine shows promise as a therapeutic agent for treating established aluminum intoxication.