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Updated: Mar 28, 2026
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
Use of chondral fragments for one stage cartilage repair: A systematic review
Davide Edoardo Bonasia1, Antongiulio Marmotti1, Federica Rosso1
1Davide Edoardo Bonasia, Antongiulio Marmotti, Federica Rosso, Gianluca Collo, Roberto Rossi, Department of Orthopaedics and Traumatology, University of Torino, AO Mauriziano "Umberto I" Hospital, 10128 Torino, Italy.
Aim:
To investigate the state of the art regarding Cartilage Autograft Implantation System (CAIS) or Particulated Juvenile Allograft Cartilage (PJAC).
Methods:
The authors searched the English literature regarding CAIS and PJAC. The search strategy was: (particulated cartilage) OR autologous cartilage fragments. All basic science articles were included. Clinical articles with less than 10 patients treated and less than 6 mo of follow-up were excluded. With these criteria, a total of 17 articles were available for the present review.
Results:
PJAC and CAIS are relatively novel techniques for cartilage repair. Good basic science evidence was described to support the concept. Although the preliminary clinical reports show encouraging results, clinical data are still limited, especially for CAIS. The indications for both techniques need to be precisely defined (age of the patients, size of the lesion, and involvement of the subchondral bone), together with other debated issues.
Conclusion:
In conclusion, the authors can state that encouraging preliminary results are available for both techniques. However, further studies are necessary to precisely determine the indications, surgical techniques, and long term outcomes for PJAC and CAIS.
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