Related Experiment Video

Updated: Mar 28, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

21.9K

Mutanome directed cancer immunotherapy

Mathias Vormehr1, Mustafa Diken2, Sebastian Boegel2

  • 1Research Center for Immunotherapy (FZI), Langenbeckstr. 1, Building 708, Mainz 55131, Germany.

Current Opinion in Immunology
|December 31, 2015
PubMed

Insights

Somatic mutations in cancer can create neo-epitopes that T cells recognize, offering a target for cancer immunotherapy. This review explores identifying and exploiting these mutations for effective cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Somatic mutations drive cancer development.
  • Neo-epitopes from mutations are recognized by T cells, potentially making them vulnerable targets.
  • T cells targeting mutations are crucial for cancer immunotherapy efficacy.

Purpose of the Study:

  • To review insights into immune recognition of neo-epitopes.
  • To present novel concepts for identifying and exploiting tumor-specific mutations.
  • To highlight therapeutic strategies targeting the cancer mutanome.

Main Methods:

  • Literature review of cancer immunotherapy and neo-epitope research.
  • Analysis of T cell recognition mechanisms for tumor mutations.
  • Discussion of methods for comprehensive mutanome identification.

Main Results:

  • Neo-epitopes are key targets for T cell-mediated tumor rejection.
  • Cancer immunotherapy efficacy is linked to T cells recognizing mutational neo-epitopes.
  • The unique mutanome of each patient presents a challenge for personalized therapy.

Conclusions:

  • Targeting neo-epitopes holds significant promise for cancer immunotherapy.
  • Advances in identifying individual tumor mutations enable personalized therapeutic strategies.
  • Exploiting the cancer mutanome is a developing frontier in oncology.

More Related Videos

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.2K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.4K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.7K