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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Merkel Cell Polyomavirus Infection and Detection
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Merkel cell carcinoma: Do you know your guidelines?

Brett A Miles1, David Goldenberg2,

  • 1Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, New York, New York.

Head & Neck
|December 31, 2015
PubMed
Summary

Merkel cell carcinoma (MCC) treatment focuses on surgical resection and adjuvant radiotherapy for high-risk patients. Ongoing research explores targeted therapies for this aggressive skin cancer, Merkel cell carcinoma (MCC).

Keywords:
MCPyV-negativeMCPyV-positiveMerkel cell carcinomaMerkel cell polyomavirus (MCPyV)cutaneous malignancies

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Area of Science:

  • Oncology
  • Dermatology
  • Cancer Research

Background:

  • Merkel cell carcinoma (MCC) is an aggressive skin cancer with increasing incidence and poor prognosis.
  • MCC is a rare cutaneous neuroendocrine malignancy.
  • Current incidence in the US is estimated at 0.32 per 100,000 people.

Purpose of the Study:

  • To review current literature on Merkel cell carcinoma (MCC) treatment.
  • To summarize National Comprehensive Cancer Network (NCCN) practice guidelines for MCC management.

Main Methods:

  • Literature review of current research on Merkel cell carcinoma (MCC).
  • Analysis of National Comprehensive Cancer Network (NCCN) guidelines for MCC treatment.

Main Results:

  • Surgical resection with negative margins is the primary therapy for Merkel cell carcinoma (MCC).
  • Adjuvant radiotherapy improves oncologic outcomes for high-risk patients and those with positive nodal disease, often following neck dissection.
  • Chemotherapy is reserved for advanced-stage or palliative care in Merkel cell carcinoma (MCC) cases.

Conclusions:

  • The discovery of Merkel cell polyomavirus (MCPyV) has advanced understanding of MCC pathogenesis.
  • Research is actively pursuing targeted and immunologic therapies for Merkel cell carcinoma (MCC).