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Related Concept Videos

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

7.9K
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
7.9K
Structure and Nomenclature of Thiols and Sulfides02:17

Structure and Nomenclature of Thiols and Sulfides

6.0K
Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...
6.0K
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

6.0K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
6.0K
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

6.2K
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
6.2K
Acid Halides to Esters: Alcoholysis01:12

Acid Halides to Esters: Alcoholysis

4.4K
Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:
4.4K
Esters to Carboxylic Acids: Saponification01:25

Esters to Carboxylic Acids: Saponification

7.1K
Esters can be hydrolyzed to carboxylic acids under acidic or basic conditions. Base-promoted hydrolysis of esters is a nucleophilic acyl substitution reaction in which esters react with an aqueous base, followed by an acid to give carboxylic acids. This reaction is also known as saponification because it forms the basis for making soaps from fats.
The reaction requires a base in stoichiometric amounts, which participates in the reaction and is not regenerated later. So, the base acts as a...
7.1K

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THE SEARCH OF COMPOUNDS WITH ANTIAGGREGATION ACTIVITY AMONG S-ESTERS OF THIOSULFONIC ACIDS.

T I Halenova, I V Nikolaeva, A V Nakonechna

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    Researchers explored new thiosulfonate derivatives for anti-thrombotic potential. Four compounds effectively inhibited platelet aggregation, with two showing significant efficacy against ADP and collagen, offering promising therapeutic avenues for thrombosis.

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    Area of Science:

    • Pharmacology and Medicinal Chemistry
    • Hematology
    • Biochemistry

    Background:

    • Platelet hyperactivation is linked to increased intravascular coagulation and thrombosis.
    • Developing novel anti-thrombotic agents targeting platelet receptors is a significant research area.
    • Modulating platelet activation and aggregation is crucial for preventing thrombotic events.

    Purpose of the Study:

    • To investigate the anti-platelet aggregation effects of newly synthesized thiosulfonate derivatives.
    • To identify specific thiosulfonate compounds with potent anti-aggregative activity in vitro.

    Main Methods:

    • In vitro testing of synthesized thiosulfonate derivatives using platelet-rich plasma.
    • Evaluation of inhibitory effects on adenosine diphosphate (ADP)- and collagen-induced platelet aggregation.
    • Dose-dependent analysis and determination of half-maximal inhibitory concentrations (IC50).

    Main Results:

    • Four thiosulfonate derivatives demonstrated significant anti-aggregative activity.
    • These compounds inhibited both ADP- and collagen-induced platelet aggregation in a dose-dependent manner.
    • Two derivatives exhibited potent inhibition, with IC50 values of 8-10 μM for ADP and 1.5-2.0 μM for collagen.

    Conclusions:

    • Newly synthesized thiosulfonate derivatives possess notable anti-platelet aggregation properties.
    • Specific compounds show promising potential as novel anti-thrombotic agents.
    • Further research into these derivatives could lead to new therapeutic strategies for thrombosis.